Super-Resolution SERS Imaging beyond the Single-Molecule Limit: An Isotope-Edited Approach
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- 作者：Eric J. Titus ; Maggie L. Weber ; Sarah M. Stranahan ; Katherine A. Willets
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：October 10, 2012
- 年：2012
- 卷：12
- 期：10
- 页码：5103-5110
- 全文大小：386K
- 年卷期：v.12,no.10(October 10, 2012)
- ISSN：1530-6992
文摘
Super-resolution imaging of single-molecule surface-enhanced Raman scattering (SM-SERS) reveals a spatial relationship between the SERS emission centroid and the corresponding intensity. Here, an isotope-edited bianalyte approach is used to confirm that shifts in the SERS emission centroid are directly linked to the changing position of the molecule on the nanoparticle surface. By working above the single-molecule limit and exploiting SERS intensity fluctuations, the SERS centroid positions of individual molecules are found to be spatially distinct.