文摘
Tobacco smoke contains thousands of chemical compounds,including many carcinogenic polycyclic aromatic hydrocarbons (PAHs). To determine the concentration ranges ofPAHs in tobacco smoke and to understand what factorsalter their levels, we quantitatively measured 14 PAHs inmainstream smoke from a transnational U.S. brand (Marlboro)and from locally popular brand cigarettes from 14 countries.We used standardized machine smoking conditions (35-mL puff volume, 60-s puff interval, and 2-s puff duration),extraction of total particulate matter from the Cambridgefilters, and gas chromatography/mass spectrometrydetection. Deliveries of total PAHs in mainstream smokeof local brands were statistically significantly higher (p <0.01) than Marlboros in seven countries. In four countries,Marlboro cigarettes had mainstream smoke total PAH levelsthat were statistically significantly higher (p < 0.01) thanlocal brands. In the remaining three countries, the differencesin PAH levels were not statistically significant. Understandard machine smoking conditions, PAH levels werenegatively correlated with cigarette filter ventilation levels.We found that several local brands containing primarily flue-cured tobacco filler had relatively high mainstreamsmoke PAH deliveries, in agreement with findings byprevious researchers that flue-cured tobacco typicallydelivers more PAHs than other tobacco types. We alsoobserved that PAHs were inversely correlated with totalcarcinogenic tobacco-specific nitrosamines and nitratecontent, but these correlations were not statistically significantat the 95% confidence interval. The findings suggest thattobacco blend and nitrate levels may influence PAH deliveries,but other factors may confound this relation.