Polarizability of G4-DNA Observed by Electrostatic Force Microscopy Measurements

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• 作者：Hezy Cohen ; Tomer Sapir ; Natalia Borovok ; Tatiana Molotsky ; Rosa Di Felice ; Alexander B. Kotlyar ; Danny Porath
• 刊名：Nano Letters
• 出版年：2007
• 出版时间：April 2007
• 年：2007
• 卷：7
• 期：4
• 页码：981 - 986
• 全文大小：426K
• 年卷期：v.7,no.4(April 2007)
• ISSN：1530-6992

文摘

G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA(dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We reportclear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA moleculeson mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.