Enantioselective Addition of Ketene Silyl Acetals to Nitrones Catalyzed by Chiral Titanium Complexes. Synthesis of Optically Active 
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- 作者：Shun-Ichi Murahashi ; Yasushi Imada ; Toru Kawakami ; Kazuhito Harada ; Yoshiharu Yonemushi ; and Naomi Tomita
- 刊名：Journal of the American Chemical Society
- 出版年：2002
- 出版时间：March 27, 2002
- 年：2002
- 卷：124
- 期：12
- 页码：2888 - 2889
- 全文大小：38K
- 年卷期：v.124,no.12(March 27, 2002)
- ISSN：1520-5126
文摘
A chiral titanium complex, Ti(O-i-Pr)4/BINOL/tert-butylcatechol, catalyzes enantioselective addition reaction of ketene silyl acetals to nitrones to give optically active 
-amino acid derivatives which are biologically active compounds and useful synthetic intermediates of natural products and pharmaceuticals such as -lactam antibiotics. The combined process of catalytic oxidation of secondary amines and enantioselective carbon-carbon bond formation of nitrones thus obtained with ketene silyl acetals provides a useful two-step method for the synthesis of optically active -amino acid derivatives and related nitrogen compounds.
-amino acid derivatives which are biologically active compounds and useful synthetic intermediates of natural products and pharmaceuticals such as -lactam antibiotics. The combined process of catalytic oxidation of secondary amines and enantioselective carbon-carbon bond formation of nitrones thus obtained with ketene silyl acetals provides a useful two-step method for the synthesis of optically active -amino acid derivatives and related nitrogen compounds.