Isoindolone Formation via Intramolecular Diels鈥揂lder Reaction
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- 作者：Matthew Ball ; Alistair Boyd ; Gwydion Churchill ; Murray Cuthbert ; Mark Drew ; Mark Fielding ; Gair Ford ; Lianne Frodsham ; Michael Golden ; Kevin Leslie ; Sarah Lyons ; Ben McKeever-Abbas ; Andrew Stark ; Paula Tomlin ; Stephen Gottschling ; Abraham Hajar ; Ji-long Jiang ; Josephine Lo ; Bob Suchozak
- 刊名：Organic Process Research & Development
- 出版年：2012
- 出版时间：May 18, 2012
- 年：2012
- 卷：16
- 期：5
- 页码：741-747
- 全文大小：252K
- 年卷期：v.16,no.5(May 18, 2012)
- ISSN：1520-586X
文摘
The intramolecular Diels鈥揂lder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, providing an efficient manufacturing route to an mGluR2 positive allosteric modulator via a 1,5,7-substituted isoindolone, is reported herein.