Nickel-Catalyzed Allylic C(sp3)鈥揊 Bond Activation of Trifluoromethyl Groups via 尾-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

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• 作者：Tomohiro Ichitsuka ; Takeshi Fujita ; Junji Ichikawa
• 刊名：ACS Catalysis
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：5
• 期：10
• 页码：5947-5950
• 全文大小：349K
• ISSN：2155-5435

文摘

The nickel-catalyzed defluorinative coupling of 2-trifluoromethyl-1-alkenes and alkynes with the aid of Et₃SiH provides 1,1-difluoro-1,4-dienes under mild reaction conditions. This reaction involves selective allylic C(sp³)鈥揊 bond activation via 尾-fluorine elimination from nickelacyclopentenes.