Cysteine-Derived Organocatalyst in a Highly Enantioselective Intramolecular Michael Reaction
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- 作者：Yujiro Hayashi ; Hiroaki Gotoh ; Tomohiro Tamura ; Hirofumi Yamaguchi ; Ryouhei Masui ; and Mitsuru Shoji
- 刊名：Journal of the American Chemical Society
- 出版年：2005
- 出版时间：November 23, 2005
- 年：2005
- 卷：127
- 期：46
- 页码：16028 - 16029
- 全文大小：60K
- 年卷期：v.127,no.46(November 23, 2005)
- ISSN：1520-5126
文摘
Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.