Total Synthesis of Schizocommunin and Revision of Its Structure

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• 作者：Koji Uehata ; Naoki Kimura ; Kazuya Hasegawa ; Shigeru Arai ; Mayumi Nishida ; Tomoo Hosoe ; Ken-ichi Kawai ; Atsushi Nishida
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：November 22, 2013
• 年：2013
• 卷：76
• 期：11
• 页码：2034-2039
• 全文大小：324K
• 年卷期：v.76,no.11(November 22, 2013)
• ISSN：1520-6025

文摘

A proposed structure for schizocommunin (Z)-1_hydroxy and its geometric isomer (E)-1_hydroxy, which exist in a keto form, has been synthesized. However, the spectroscopic data of (Z)-1_keto and (E)-1_keto were not consistent with those reported for natural schizocommunin. After reinvestigating the spectral data for natural schizocommunin, we synthesized the quinazolinone derivative (Z)-2 as a revised structure for schizocommunin. All of the spectral data of (Z)-2 were completely identical to those reported for natural schizocommunin. (Z)-2 showed moderate antiproliferative activity.