Effect of Selenium- and Glutathione-Enriched Yeast Supplementation on a Combined Atherosclerosis and Diabetes Hamster Model

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• 作者：Gabriel A. Agbor ; Joe A. Vinson ; Shachi Patel ; Kunal Patel ; Jenyne Scarpati ; Drew Shiner ; Forbes Wardrop ; Thomas A. Tompkins
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2007
• 出版时间：October 17, 2007
• 年：2007
• 卷：55
• 期：21
• 页码：8731 - 8736
• 全文大小：116K
• 年卷期：v.55,no.21(October 17, 2007)
• ISSN：1520-5118

文摘

Selenium has a central role in antioxidant pathways as a cofactor to glutathione peroxidase. The present study evaluated the effects of four different preparations of inactivated yeast containing various concentrations of selenium and glutathione on a combined atherosclerosis and diabetes hamster model. The hamsters were supplemented with the yeast products for three months. The enriched yeast with the highest selenium and glutathione levels reduced the weight loss induced by diabetes, inhibited an increase in plasma cholesterol and triglyceride caused by a high-cholesterol and high-fat diet, increased the time taken for oxidation of lower density lipoproteins (lag time), and inhibited the formation of atherosclerosis better than low selenium/glutathione yeast supplementation. It was concluded that the yeast prepared to provide high selenium and high glutathione was the best for effecting beneficial changes in glutathione, cholesterol, atherosclerosis, and for demonstrating an antioxidant effect. The high selenium and low glutathione yeast was the best for improving selenium and glucose levels.