Formal Total Synthesis of Manzacidin C Based on Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Imines

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• 作者：Thu Minh Thi Tong ; Takahiro Soeta ; Takuya Suga ; Keisuke Kawamoto ; Yoshihito HayashiYutaka Ukaji
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：1969-1976
• 全文大小：511K
• ISSN：1520-6904

文摘

An enantioselective formal total synthesis of (+)-manzacidin C is described. A key feature of the synthesis is the construction of two chiral centers via the asymmetric 1,3-dipolar cycloaddition of an azomethine imine to methallyl alcohol by the use of (S,S)-DIPT as a chiral auxiliary.