Enforcing Molecule’s π-Conjugation and Consequent Formation of the Acid−Acid Homosynthon over the Acid−Pyridine Heterosynthon in 2-Anilinonicotinic Acids

详细信息    查看全文

• 作者：Sihui Long ; Tonglei Li
• 刊名：Crystal Growth & Design
• 出版年：2010
• 出版时间：June 2, 2010
• 年：2010
• 卷：10
• 期：6
• 页码：2465-2469
• 全文大小：797K
• 年卷期：v.10,no.6(June 2, 2010)
• ISSN：1528-7505

文摘

Two different synthons, acid−acid and acid−pyridine, are present in the crystal structures of 2-(phenylamino)nicotinic acid. The intermolecular hydrogen-bonding motifs are determined by molecular conformation and conformational energy. By covalently linking electron-withdrawing groups to the phenyl ring, it is possible to strengthen the molecule’s global π-conjugation and thereby lead to only the acid−acid homosynthon in crystal packing and prohibit the competing acid−pyridine heterosynthon.