A Citric Acid-Derived Ligand for Modular Functionalization of Metal Oxide Surfaces via 鈥淐lick鈥?Chemistry

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• 作者：Lee M. Bishop ; Joseph C. Yeager ; Xin Chen ; Jamie N. Wheeler ; Marco D. Torelli ; Michelle C. Benson ; Steven D. Burke ; Joel A. Pedersen ; Robert J. Hamers
• 刊名：Langmuir
• 出版年：2012
• 出版时间：January 17, 2012
• 年：2012
• 卷：28
• 期：2
• 页码：1322-1329
• 全文大小：393K
• 年卷期：v.28,no.2(January 17, 2012)
• ISSN：1520-5827

文摘

Citric acid is a widely used surface-modifying ligand for growth and processing of a variety of nanoparticles; however, the inability to easily prepare derivatives of this molecule has restricted the development of versatile chemistries for nanoparticle surface functionalization. Here, we report the design and synthesis of a citric acid derivative bearing an alkyne group and demonstrate that this molecule provides the ability to achieve stable, multidentate carboxylate binding to metal oxide nanoparticles, while also enabling subsequent multistep chemistry via the Cu(I)-catalyzed azide鈥揳lkyne cycloaddition (CuAAC) reaction. The broad utility of this strategy for the modular functionalization of metal oxide surfaces was demonstrated by its application in the CuAAC modification of ZnO, Fe₂O₃, TiO₂, and WO₃ nanoparticles.