Synthesis and Absolute Configuration of Novel N,O-Psiconucleosides Using (R)-N-Phenylpantolactam as a Resolution Agent

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• 作者：Pelayo Camps ; Tà ; nia Gó ; mez ; Diego Muñ ; oz-Torrero ; Jordi Rull ; Laura Sá ; nchez ; Francesca Boschi ; Mauro Comes-Franchini ; Alfredo Ricci ; Teresa Calvet ; Mercè ; Font-Bardia ; Erik
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：September 5, 2008
• 年：2008
• 卷：73
• 期：17
• 页码：6657-6665
• 全文大小：308K
• 年卷期：v.73,no.17(September 5, 2008)
• ISSN：1520-6904

文摘

A series of novel N,O-psiconucleosides has been prepared in both enantiomeric forms by resolution of an advanced racemic synthetic intermediate using (R)-N-phenylpantolactam as a chiral resolution agent. The absolute configuration of all of these compounds has been unequivocally established by chemical correlation with the novel (R)- or (S)-1-methyl-5-phenylpyrrolidine-2,3-dione, prepared from the known (R)- and (S)-1-methyl-5-phenylpyrrolidin-2-one, respectively.