Hypoxylonols C鈥揊, Benzo[j]fluoranthenes from Hypoxylon truncatum

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• 作者：Miyuki Fukai ; Mariko Tsukada ; Kazuhiko Miki ; Toshihiro Suzuki ; Takashi Sugita ; Kaoru Kinoshita ; Kunio Takahashi ; Motoo Shiro ; Kiyotaka Koyama
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：January 27, 2012
• 年：2012
• 卷：75
• 期：1
• 页码：22-25
• 全文大小：209K
• 年卷期：v.75,no.1(January 27, 2012)
• ISSN：1520-6025

文摘

Four novel benzo[j]fluoranthene derivatives, hypoxylonols C (3), D (4), E (5), and F (6), have been isolated from the mushroom Hypoxylon truncatum, together with two known benzo[j]fluoranthene derivatives, hypoxylonols A (1) and B (2). The structures were established by analysis of NMR spectroscopic data and X-ray diffraction data. Compounds 4 and 5 showed antiproliferative activity against HUVECs (human umbilical vein endothelial cells) and HUAECs (human umbilical artery endothelial cells).