Antiangiogenic Activity of Hypoxylonol C

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• 作者：Miyuki Fukai ; Toshihiro Suzuki ; Ikuko Nagasawa ; Kaoru Kinoshita ; Kunio Takahashi ; Kiyotaka Koyama
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：1065-1068
• 全文大小：323K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related to cell cycle and adhesion were down-regulated. The down-regulation of mRNA levels of cell cycle and adhesion genes was confirmed by real-time RT-PCR. Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1).