Stereoselective Total Synthesis of (−)-Renieramycin T

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• 作者：Masashi Yokoya ; Ryoko Toyoshima ; Toshihiro Suzuki ; Vy H. Le ; Robert M. Williams ; Naoki Saito
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：81
• 期：10
• 页码：4039-4047
• 全文大小：532K
• 年卷期：0
• ISSN：1520-6904

文摘

A stereoselective total synthesis of (−)-Renieramycin T (1t) from a key tetrahydroisoquinoline intermediate previously utilized in our formal total synthesis of Ecteinascidin 743 is described. The synthesis features a concise approach for construction of the pentacyclic framework using a Pictet–Spengler cyclization of bromo-substituted carbinolamine 17, which obviates the regioselectivity problem of the Pictet–Spengler cyclization. The results of cytotoxicity studies are also presented.