Integrated Framework for Identifying Toxic Transformation Products in Complex Environmental Mixtures

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• 作者：Leah Chibwe ; Ivan A. Titaley ; Eunha HohStaci L. Massey Simonich
• 刊名：Environmental Science & Technology Letters
• 出版年：2017
• 出版时间：February 14, 2017
• 年：2017
• 卷：4
• 期：2
• 页码：32-43
• 全文大小：649K

文摘

Complex environmental mixtures consist of hundreds to thousands of unknown and unregulated organic compounds that may have toxicological relevance, including transformation products (TPs) of anthropogenic organic pollutants. Nontargeted analysis and suspect screening analysis offer analytical approaches for potentially identifying these toxic transformation products. However, additional tools and strategies are needed to reduce the number of chemicals of interest and focus analytical efforts on chemicals that may pose risks to humans and the environment. This brief review highlights recent developments in this field and suggests an integrated framework that incorporates complementary instrumental techniques, computational chemistry, and toxicity analysis, for prioritizing and identifying toxic TPs in the environment.