Rapid-Response Fluorescent Probe for Hydrogen Peroxide in Living Cells Based on Increased Polarity of C鈥揃 Bonds

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• 作者：Wei Zhang ; Wei Liu ; Ping Li ; Fang Huang ; Hui Wang ; Bo Tang
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：October 6, 2015
• 年：2015
• 卷：87
• 期：19
• 页码：9825-9828
• 全文大小：259K
• ISSN：1520-6882

文摘

Hydrogen peroxide (H₂O₂) as a reactive oxygen species (ROS) plays a crucial role in oxidative stress and signal transduction of organisms. Currently, a fluorescence probe has proven to be a powerful tool for the H₂O₂ analysis. However, the common problem is the slow response, causing difficulty in tracking H₂O₂ in situ. Herein, we describe a novel aggregation-induced emission (AIE) fluorescence probe based on increased polarity of C鈥揃 bonds that is well suited for monitoring H₂O₂ rapidly and selectively. Importantly, the probe was successfully applied to visualize H₂O₂ levels in living cells, which provides a rapid-response and highly selective fluorescence tool for monitoring of the H₂O₂ levels in biological process.