Dual Signaling Molecule Sensor for Rapid Detection of Hydrogen Sulfide Based on Modified Tetraphenylethylene

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• 作者：Wei Zhang ; Junqing Kang ; Ping Li ; Hui Wang ; Bo Tang
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：September 1, 2015
• 年：2015
• 卷：87
• 期：17
• 页码：8964-8969
• 全文大小：330K
• ISSN：1520-6882

文摘

A dual signaling molecule sensor has received increasing attention owing to its ability to read out target analytes with more than one transduction channel and thus make the results more convincing. Here we have developed a dual signaling molecule sensor that is well suited for monitoring hydrogen sulfide (H₂S) levels through fluorescence, UV鈥搗isible adsorption, and visual mode. Results showed the selective and instantaneous responses of sensor toward intracellular H₂S. Moreover, the sensor was successfully applied to imaging of H₂S levels in Caenorhabditis elegans (C. elegans) and observed the changes of H₂S under starvation of C. elegans. Altogether, the sensor was proved to be a useful tool for tracking H₂S levels in cells and in vivo. The merits of two kinds of independent signaling molecules allow us to select different output modes according to the different samples.