Dispersion in Compartmentalized Flow Systems: Influence of Flow Patterns on Reactivity
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- 作者：Neil Hawbaker ; Eric Wittgrove ; Bianca Christensen ; Neal Sach ; Donna G. Blackmond
- 刊名：Organic Process Research & Development
- 出版年：2016
- 出版时间：February 19, 2016
- 年：2016
- 卷：20
- 期：2
- 页码：465-473
- 全文大小：600K
- ISSN：1520-586X
文摘
Rapid reaction screening in flow systems may help to reduce the time and material required to optimize, scale-up, and implement a flow process. Compartmentalization using small fluorous plugs has been implemented in several commercial reactors as a means for running a large number of isolated reactions in series within a flow reactor. Dye tracking, visual mixing, and reactivity studies are used to better understand the factors controlling dispersion within a commercial reactor. The role of dispersion on reactivity is elucidated using model reactions, and an optimized method for performing high-throughput screening is proposed.