Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation
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- 作者：Nathan Lamarre-Vincent and Linda C. Hsieh-Wilson
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：June 4, 2003
- 年：2003
- 卷：125
- 期：22
- 页码：6612 - 6613
- 全文大小：66K
- 年卷期：v.125,no.22(June 4, 2003)
- ISSN：1520-5126
文摘
We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAFII130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain.