Synthesis of Spirocarbamate Oxindoles via Intramolecular Trapping of a 尾-Silyl Carbocation by an N-Boc Group
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- 作者：Benjamin H. Shupe ; Emily E. Allen ; Jacob P. MacDonald ; Sean O. Wilson ; Annaliese K. Franz
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：July 5, 2013
- 年：2013
- 卷：15
- 期：13
- 页码：3218-3221
- 全文大小：251K
- 年卷期：v.15,no.13(July 5, 2013)
- ISSN：1523-7052
文摘
We report the Lewis acid catalyzed additions of allylsilanes to N-Boc-iminooxindoles and the formation of novel silicon-containing spirocarbamates via intramolecular trapping of a 尾-silyl carbocation by an N-Boc group. Several transformations display the synthetic utility of these spirocarbamate oxindoles, including a reductive cyclization to access new silylated furoindoline derivatives.