Ribosomal Route to Small-Molecule Diversity
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- 作者：Ma. Diarey B. Tianero ; Mohamed S. Donia ; Travis S. Young ; Peter G. Schultz ; Eric W. Schmidt
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：January 11, 2012
- 年：2012
- 卷：134
- 期：1
- 页码：418-425
- 全文大小：508K
- 年卷期：v.134,no.1(January 11, 2012)
- ISSN：1520-5126
文摘
The cyanobactin ribosomal peptide (RP) natural product pathway was manipulated to incorporate multiple tandem mutations and non-proteinogenic amino acids, using eight heterologous components simultaneously expressed in Escherichia coli. These studies reveal the potential of RPs for the rational synthesis of complex, new small molecules over multiple-step biosynthetic pathways using simple genetic engineering.