Monopicolinate-dipicolyl Derivative of Triazacyclononane for Stable Complexation of Cu2+ and 64Cu2+

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• 作者：Melissa Roger ; Lu铆s M. P. Lima ; Mathieu Frindel ; Carlos Platas-Iglesias ; Jean-Fran莽ois Gestin ; Rita Delgado ; V茅ronique Patinec ; Rapha毛l Tripier
• 刊名：Inorganic Chemistry
• 出版年：2013
• 出版时间：May 6, 2013
• 年：2013
• 卷：52
• 期：9
• 页码：5246-5259
• 全文大小：550K
• 年卷期：v.52,no.9(May 6, 2013)
• ISSN：1520-510X

文摘

The synthesis and characterization of Hno1pa2py, a new tacn-based ligand, is reported. The complexation process with Cu²⁺ was proved to be very fast even in acidic medium. Potentiometric titrations allowed us to establish that Hno1pa2py exhibits an overall low basicity as well as a high selectivity for Cu²⁺ over Zn²⁺ cations. The copper(II) complex was synthesized and characterized using UV鈥搗is and EPR spectroscopies and density functional theory (DFT) calculations. The studies clearly showed that the [Cu(no1pa2py)]⁺ complex is present in solution as a mixture of two isomers in which the ligand is coordinated to the metal center using a N₅O donor set with the metal center in a distorted octahedral geometry. The very high kinetic inertness of the [Cu(no1pa2py)]⁺ complex was demonstrated by using acid-assisted dissociation assays as well as cyclic voltammetry. Preliminary investigations of ⁶⁴Cu complexation were performed to validate the potential use of such chelating agent for further application in nuclear medicine. The X-ray crystal structures of copper(II) complexes of L1, the ester derivative of Hno1pa2py, have been determined.