MoS2–Gd Chelate Magnetic Nanomaterials with Core–Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging

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• 作者：Rajeshkumar Anbazhagan ; Yu-An Su ; Hsieh-Chih Tsai ; Ru-Jong Jeng
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：January 27, 2016
• 年：2016
• 卷：8
• 期：3
• 页码：1827-1835
• 全文大小：655K
• ISSN：1944-8252

文摘

Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core–shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin–lattice relaxation time (T₁) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core–shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging.