Pilot-Scale Production of Dimethyl 1,4-Cubanedicarboxylate

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• 作者：Michael J. Falkiner ; Stuart W. Littler ; Kenneth J. McRae ; G. Paul Savage ; John Tsanaktsidis
• 刊名：Organic Process Research & Development
• 出版年：2013
• 出版时间：December 20, 2013
• 年：2013
• 卷：17
• 期：12
• 页码：1503-1509
• 全文大小：309K
• 年卷期：v.17,no.12(December 20, 2013)
• ISSN：1520-586X

文摘

A scalable process for the preparation of high purity dimethyl 1,4-cubanedicarboxylate (3) is reported. The work described herein builds on previous synthetic work from this and other laboratories, to provide a reliable process that can be used to prepare multigram quantities of 3 in a partially telescoped, 8 step process, with minimal purification of intermediates.