Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Indole Complexes as Sensitive Probes for Indole-Binding Proteins
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- 作者：Kenneth Kam-Wing Lo ; Ka-Shing Sze ; Keith Hing-Kit Tsang ; Nianyong Zhu
- 刊名：Organometallics
- 出版年：2007
- 出版时间：July 2, 2007
- 年：2007
- 卷：26
- 期：14
- 页码：3440 - 3447
- 全文大小：133K
- 年卷期：v.26,no.14(July 2, 2007)
- ISSN：1520-6041
文摘
Luminescent tricarbonylrhenium(I) dipyridoquinoxaline indole complexes [Re(N-N)(CO)3(L)](CF3SO3) (N-N = dipyrido[3,2-f:2',3'-h]quinoxaline (dpq), L = N-(3-pyridoyl)tryptamine (py-3-CONHC2H4-indole) (1a), N-(N-(3-pyridoyl)-6-aminohexanoyl)tryptamine (py-3-CONHC5H10CONHC2H4-indole) (1b);N-N = 2-(n-butylamido)dipyrido[3,2-f:2',3'-h]quinoxaline (dpqa), L = py-3-CONHC2H4-indole (2a),py-3-CONHC5H10CONHC2H4-indole (2b)) and their indole-free counterparts [Re(N-N)(CO)3(py-3-CONH-Et)](CF3SO3) (py-3-CONH-Et = N-ethyl-(3-pyridyl)formamide; N-N = dpq (1c), dpqa (2c))have been synthesized and characterized. The crystal structure of a related complex, [Re(dpqa)(CO)3(pyridine)](PF6), has also been studied. All the complexes exhibited triplet metal-to-ligand charge-transfer(3MLCT) (d
(Re) 
*(N-N)) emission in fluid solutions at 298 K and in alcohol glass at 77 K. Theemission quantum yields of the complexes were reduced upon changing from CH2Cl2 to aqueous buffer.The reduction was much more significant for the dpqa complexes than the dpq complexes due to thehydrogen-bonding interaction of the amide substituent of the dpqa ligand with water molecules. Theinteractions of these tricarbonylrhenium(I) complexes with indole-binding proteins including bovineserum albumin and tryptophanase have been studied by emission titrations and inhibition assays,respectively.
(Re) *(N-N)) emission in fluid solutions at 298 K and in alcohol glass at 77 K. Theemission quantum yields of the complexes were reduced upon changing from CH2Cl2 to aqueous buffer.The reduction was much more significant for the dpqa complexes than the dpq complexes due to thehydrogen-bonding interaction of the amide substituent of the dpqa ligand with water molecules. Theinteractions of these tricarbonylrhenium(I) complexes with indole-binding proteins including bovineserum albumin and tryptophanase have been studied by emission titrations and inhibition assays,respectively.