Symbiospirols: Novel Long Carbon-Chain Compounds Isolated from Symbiotic Marine Dinoflagellate Symbiodinium sp.

详细信息    查看全文

• 作者：Yuta Tsunematsu ; Osamu Ohno ; Kaori Konishi ; Kaoru Yamada ; Masami Suganuma ; Daisuke Uemura
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：May 21, 2009
• 年：2009
• 卷：11
• 期：10
• 页码：2153-2156
• 全文大小：129K
• 年卷期：v.11,no.10(May 21, 2009)
• ISSN：1523-7052

文摘

Symbiospirols A, B, and C, long carbon-chain compounds with a molecular weight of 1207 were isolated from the cultured symbiotic dinoflagellate Symbiodinium sp. Their planar structures and partial relative stereochemistries were elucidated based on 1D and 2D NMR spectra and a degradation reaction. Symbiospirols consisted of a C67-linear chain with a β,β′-dihydroxyl ketone moiety, eight hydroxyl groups, one tetrahydropyran ring, and two 1,6-dioxaspiro[4,4]nonane rings. Symbiospirol A had an inhibitory effect against l-phosphatidylserine-induced PKC activation.