Reverse the Diastereoselectivity of the Rh(I)-Catalyzed Pauson-Khand Cycloaddition

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• 作者：Mark Turlington ; Lin Pu
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：13
• 期：16
• 页码：4332-4335
• 全文大小：796K
• 年卷期：v.13,no.16(August 19, 2011)
• ISSN：1523-7052

文摘

It is discovered that the diastereoselectivity of the Rh(I)-catalyzed Pauson鈥揔hand cycloaddition of chiral enynes can be reversed to generate the trans diastereomer as the major product in the absence of a chelate phosphine ligand when the substrate contains an appropriate functional group capable of chelate coordination to the Rh(I) center. This expands the application of the Rh(I)-based catalytic processes to prepare both the cis and trans stereoisomers.