Antcamphins A–L, Ergostanoids from Antrodia camphorata
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- 作者：Yun Huang ; Xionghao Lin ; Xue Qiao ; Shuai Ji ; Kedi Liu ; Chi-tai Yeh ; Yew-min Tzeng ; Dean Guo ; Min Ye
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：January 24, 2014
- 年：2014
- 卷：77
- 期：1
- 页码：118-124
- 全文大小：292K
- ISSN：1520-6025
文摘
Twelve ergostanoids, named antcamphins A鈥揕 (1鈥?b>12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis鈥?i>trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5鈥?b>12 are four pairs of C-25 epimers. The structures of 1鈥?b>12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5鈥?b>12 were determined by the modified Mosher鈥檚 method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.