Sesquiterpene Glycosides from Cosmospora joca

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• 作者：Tzong-Huei Lee ; Chung-Kuang Lu ; Guei-Jane Wang ; Ya-Chih Chang ; Wen-Bin Yang ; Yu-Min Ju
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：July 22, 2011
• 年：2011
• 卷：74
• 期：7
• 页码：1561-1567
• 全文大小：833K
• 年卷期：v.74,no.7(July 22, 2011)
• ISSN：1520-6025

文摘

Five novel sesquiterpene glycosides, namely, cosmosporasides A鈥揈 (1鈥?b>5), were isolated from the ethyl acetate extract of the fermented broth of Cosmospora joca. The structures of 1鈥?b>5 were elucidated on the basis of spectroscopic data analyses, monosaccharide composition analyses, and monosaccharide chirality analyses. The relative configuration of the sesquiterpene moiety of 3鈥?b>5 was determined by J-based configuration analyses and supported by NOESY assignments. The inhibitory effects of 1鈥?b>5 on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated; all except 3 inhibited NO production at 100 渭M. 4 was the most potent, with an average maximum inhibition and a median inhibitory concentration value of 71.70 卤 1.23% and 65.98 卤 0.53 渭M, respectively.