Triterpene Glycosides from the Underground Parts of Caulophyllum thalictroides
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- 作者：Yukiko Matsuo ; Kazuki Watanabe ; Yoshihiro Mimaki
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：June 26, 2009
- 年：2009
- 卷：72
- 期：6
- 页码：1155-1160
- 全文大小：132K
- 年卷期：v.72,no.6(June 26, 2009)
- ISSN：1520-6025
文摘
A total of 22 triterpene glycosides, including 10 new compounds (1−10), were isolated from the underground parts of Caulophyllum thalictroides. The structures of the new glycosides were determined on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR data, and of hydrolytic cleavage followed by chromatographic or spectroscopic analyses. All 22 compounds were evaluated for cytotoxicity against HL-60 human leukemia cells. The triterpene monodesmosides based on oleanolic acid (1 and 11−16) showed cytotoxic activity against HL-60 cells with IC50 values that ranged from 3.4 to 15.9 μg/mL.