Total Synthesis of Spirobacillene A

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• 作者：William P. Unsworth ; James D. Cuthbertson ; Richard J. K. Taylor
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 5, 2013
• 年：2013
• 卷：15
• 期：13
• 页码：3306-3309
• 全文大小：291K
• 年卷期：v.15,no.13(July 5, 2013)
• ISSN：1523-7052

文摘

The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus fusiformis, is reported. A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a potential biosynthesis of the natural product.