An Expedient Protecting-Group-Free Total Synthesis of (卤)-Dievodiamine

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• 作者：William P. Unsworth ; Christiana Kitsiou ; Richard J. K. Taylor
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 5, 2013
• 年：2013
• 卷：15
• 期：13
• 页码：3302-3305
• 全文大小：255K
• 年卷期：v.15,no.13(July 5, 2013)
• ISSN：1523-7052

文摘

The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described. The convergent synthesis was performed without protecting groups, delivering a route that is short and high yielding and uses limited chromatography. Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis.