Direct Imine Acylation: Synthesis of the Proposed Structures of 鈥楿penamide

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• 作者：William P. Unsworth ; Katherine A. Gallagher ; Micka毛l Jean ; Jan Peter Schmidt ; Louis J. Diorazio ; Richard J. K. Taylor
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：15
• 期：2
• 页码：262-265
• 全文大小：303K
• 年卷期：v.15,no.2(January 18, 2013)
• ISSN：1523-7052

文摘

The synthesis of the two proposed structures of macrocyclic marine natural product 鈥榰penamide is reported. The key step utilizes direct imine acylation (DIA) with a protected 尾-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction.