Glycogen Synthase Kinase 3 (GSK3)
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- 作者：Martin H. Maurer ; Jens O. Brö ; mme ; Robert E. Feldmann ; Jr. ; Anne Jä ; rve ; Fatemeh Sabouri ; Heinrich F. Bü ; rgers ; Dominik W. Schelshorn ; Carola Krü ; ger ; Armin Schneider ; Wolfgang Kuschins
- 刊名：Journal of Proteome Research
- 出版年：2007
- 出版时间：March 2007
- 年：2007
- 卷：6
- 期：3
- 页码：1198 - 1208
- 全文大小：638K
- 年卷期：v.6,no.3(March 2007)
- ISSN：1535-3907
文摘
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen SynthaseKinase 3
(GSK3) as a central regulator for differentiation and cell survival of adult neural stem cells.Detected by proteomic approaches, members of the Wnt/-catenin signaling pathway appear toparticipate in enhanced neuronal differentiation and activated transcription of -catenin target genesduring GSK3 inhibition, associated with decreased apoptosis.
(GSK3) as a central regulator for differentiation and cell survival of adult neural stem cells.Detected by proteomic approaches, members of the Wnt/-catenin signaling pathway appear toparticipate in enhanced neuronal differentiation and activated transcription of -catenin target genesduring GSK3 inhibition, associated with decreased apoptosis.