On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase
Kinase 3
(GSK3
) as a central regulator for differentiation and cell survival of adult neural stem cells.Detected by proteomic approaches, members of the Wnt/
-catenin signaling pathway appear toparticipate in enhanced neuronal differentiation and activated transcription of
-catenin target genesduring GSK3
inhibition, associated with decreased apoptosis.