Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines
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- 作者：Waleed M. Hussein ; Saori Mukaida ; Fazren Azmi ; Stacey Bartlett ; Celine Olivier ; Michael R. Batzloff ; Michael F. Good ; Mariusz SkwarczynskiIstvan Toth
- 刊名：ACS Medicinal Chemistry Letters
- 出版年：2017
- 出版时间：February 9, 2017
- 年：2017
- 卷：8
- 期：2
- 页码：227-232
- 全文大小：402K
- ISSN：1948-5875
文摘
Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund’s adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.