Synthesis of Aminocarbonyl N-Acylhydrazones by a Three-Component Reaction of Isocyanides, Hydrazonoyl Chlorides, and Carboxylic Acids

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• 作者：Mariateresa Giustiniano ; Fiorella Meneghetti ; Valentina Mercalli ; Monica Varese ; Francesco Giustiniano ; Ettore Novellino ; Gian Cesare Tron
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：October 17, 2014
• 年：2014
• 卷：16
• 期：20
• 页码：5332-5335
• 全文大小：330K
• ISSN：1523-7052

文摘

A novel one-pot multicomponent synthesis of 伪-aminocarbonyl N-acylhydrazones starting from readily available hydrazonoyl chlorides, isocyanides, and carboxylic acids is reported. The strategy exploits the ability of the carboxylic acid as a third component to suppress all competing reactions between nitrile imines and isocyanides, channeling the course of the reaction toward the formation of this novel class of compounds.