Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)-Chlorooximes, Isocyanides, and Electron-Deficient Phenols
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- 作者：Valentina Mercalli ; Mariateresa Giustiniano ; Erika Del Grosso ; Monica Varese ; Hilde Cassese ; Alberto Massarotti ; Ettore Novellino ; Gian Cesare Tron
- 刊名：ACS Combinatorial Science
- 出版年：2014
- 出版时间：November 10, 2014
- 年：2014
- 卷：16
- 期：11
- 页码：602-605
- 全文大小：221K
- ISSN：2156-8944
文摘
A library of 41 aryloxyimino amides was prepared via solution phase parallel synthesis by extending the multicomponent reaction of (Z)-chlorooximes and isocyanides to the use of electron-deficient phenols. The resulting aryloxyiminoamide derivatives can be used as intermediates for the synthesis of benzo[d]isoxazole-3-carboxamides, dramatically reducing the number of synthetic steps required by other methods reported in literature.