Process Intensification of the Suzuki鈥揗iyaura Reaction over Sol鈥揋el Entrapped Catalyst SiliaCat DPP-Pd Under Conditions of Continuous Flow

详细信息    查看全文

• 作者：Valerica Pandarus ; Genevi猫ve Gingras ; Fran莽ois B茅land ; Rosaria Ciriminna ; Mario Pagliaro
• 刊名：Organic Process Research & Development
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：18
• 期：11
• 页码：1550-1555
• 全文大小：341K
• ISSN：1520-586X

文摘

We report the newly developed conditions for the process intensification of the Suzuki鈥揗iyaura reaction under flow over sol鈥揼el entrapped SiliaCat DPP-Pd catalyst with the aim of practical applications. Considerably more concentrated solutions (0.5鈥?.0 M) are applied, and flow rate is increased up to the practically relevant 1.0 mL/min threshold. Results indicate complete coupling conversion of several different aryl halides and provide important information of general validity of vital importance for successful process intensification.