A Robust, Streamlined Approach to Bosutinib Monohydrate

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• 作者：Gregory J. Withbroe ; Chris Seadeek ; Kevin P. Girard ; Steven M. Guinness ; Brian C. Vanderplas ; Rajappa Vaidyanathan
• 刊名：Organic Process Research & Development
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：17
• 期：3
• 页码：500-504
• 全文大小：293K
• 年卷期：v.17,no.3(March 15, 2013)
• ISSN：1520-586X

文摘

This article describes a systematic approach used to streamline the process for the isolation of bosutinib monohydrate, a promiscuous solvate former. A thorough understanding of the complex solid form landscape was garnered, and this knowledge was used to develop a process that routinely delivered the correct solid form and excellent purity at the end of the last bond-formation step, without the need for additional recrystallization and/or solid form conversion steps.