Losartan-Antioxidant Hybrids: Novel Molecules for the Prevention of Hypertension-Induced Cardiovascular Damage

详细信息    查看全文

• 作者：Gonzalo Garca ; Manuel Rodrguez-Puyol ; Ramn Alajarn ; Isabel Serrano ; Patricia Snchez-Alonso ; Mercedes Griera ; Juan J. Vaquero ; Diego Rodrguez-Puyol ; Julio lvarez-Builla ; Mara L. Dez-Marqus
• 刊名：Journal of Medicinal Chemistry
• 出版年：2009
• 出版时间：November 26, 2009
• 年：2009
• 卷：52
• 期：22
• 页码：7220-7227
• 全文大小：876K
• 年卷期：v.52,no.22(November 26, 2009)
• ISSN：1520-4804

文摘

We report the first examples of a new series of antioxidant-sartan hybrids (AO-sartans), which were made by adding an antioxidant fragment to the hydroxymethyl side chain of losartan. Experiments performed in cultured cells demonstrate that these new hybrids retain the ability to block the angiotensin II effect with increased antioxidant ability. In hypertensive rats, these compounds show properties that suggest they may be more useful than losartan for controlling hypertension and preventing hypertension-induced cardiovascular damage.