Practical Large-Scale Preparation of (卤)-2-exo-Norbornyl Carboxylic Acid and Its Improved Isolation As the Sodium Salt

详细信息    查看全文

• 作者：Jianxin Gu ; Thomas Storz ; Frederick Vyverberg ; Charles Wu ; Richard J. Varsolona ; Karen Sutherland
• 刊名：Organic Process Research & Development
• 出版年：2011
• 出版时间：July 15, 2011
• 年：2011
• 卷：15
• 期：4
• 页码：942-945
• 全文大小：718K
• 年卷期：v.15,no.4(July 15, 2011)
• ISSN：1520-586X

文摘

A practical, robust, and high-yielding three-step鈭抩ne-pot procedure for the diastereoselective synthesis of (卤)-2-exo-norbornyl carboxylic acid starting from norbornylene has been found and demonstrated on multikilogram scale, setting a new benchmark for low-pressure hydroformylation of cyclic, bridged olefins. The newly found, nonhygroscopic crystalline sodium salt of this acid provides a practical isolation point.