Antiatherosclerotic Effects of Artemisia princeps Pampanini cv. Sajabal in LDL Receptor Deficient Mice

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• 作者：Jong-Min Han^† ; ; Min-Jung Kim^† ; ; Seung-Hwa Baek^† ; ; Sojin An^† ; ; Yue-Yan Jin^† ; ; Hae-Gon Chung^‡ ; ; Nam-In Bae
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：February 25, 2009
• 年：2009
• 卷：57
• 期：4
• 页码：1267-1274
• 全文大小：440K
• 年卷期：v.57,no.4(February 25, 2009)
• ISSN：1520-5118

文摘

Antiatherosclerotic effects of ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal (ESJ) were investigated in low-density lipoprotein receptor deficient (LDLR^−/−) mice. The Western diet-induced high levels of total cholesterol and triglyceride were similar in the ESJ and control groups. However, circulating oxidized LDL was significantly decreased in the ESJ group (p < 0.05). ESJ also markedly decreased aortic expression levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and reduced the aortic lesion formation and macrophage accumulation by 36.7% (p < 0.05) and 43% (p < 0.01) in the control group, respectively. Additionally, ESJ inhibited atherogenic properties with cytokine-induced surface expression of cell adhesion molecules, chemokines, and monocyte adhesion to the human umbilical vein endothelial cells (HUVECs), and simultaneously suppressed nuclear factor-κB (NF-κB) activation. These results suggest that ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal contributes to the antiatherosclerotic and anti-inflammatory activities in LDLR^−/− mice.