An efficient synthetic route to the ABC tricyclic core of 1
-alkyldaphnanes has been developed. The conformational bias imparted by theC6-C9 oxo-bridge of BC-ring system
12 was used to elaborate the ABC-ring system precursor including the introduction of the
-C5 hydroxylgroup. A completely diastereoselective palladium-catalyzed enyne cyclization was then employed to establish the A-ring with a C1 appendage.