Palladium-Catalyzed, Multicomponent Approach to β-Lactams via Aryl Halide Carbonylation
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- 作者：Gerardo M. Torres ; Maximiliano De La Higuera Macias ; Jeffrey S. Quesnel ; Oliver P. Williams ; Veeranna Yempally ; Ashfaq A. Bengali ; Bruce A. Arndtsen
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：December 16, 2016
- 年：2016
- 卷：81
- 期：24
- 页码：12106-12115
- 全文大小：662K
- ISSN：1520-6904
文摘
A palladium-catalyzed multicomponent method for the synthesis of β-lactams from imines, aryl halides, and CO has been developed. This transformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(PtBu3)2 and provides a route to prepare these products from five separate reagents. A diverse range of polysubstituted β-lactams can be generated by systematic variation of the substrates. This methodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic β-lactams in good yields and selectivity.