Biogenetic Relationships between Annonaceous Acetogenins: Squamocin Is Not a Precursor of Chamuvarinin Based on a Semisynthetic Study

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• 作者：S&eacute ; verine Derbr&eacute ; Erwan Poupon ; Christophe Gleye ; Reynald Hocquemiller
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：70
• 期：2
• 页码：300 - 303
• 全文大小：103K
• 年卷期：v.70,no.2(February 2007)
• ISSN：1520-6025

文摘

In the course of reactivity studies on squamocin (1), a highly cytotoxic acetogenin from the plant family Annonaceae,two diastereomers, 3 and 4, of chamuvarinin (2) were synthesized. Based on this, a plausible relative configuration wasproposed for 2, demonstrating the absence of any biogenetic link between 1 and 2. The new analogues 3, 4, and 7 werealso tested for their ability to induce apoptosis.