Photoinitiated Synthesis of Self-Assembled Vesicles

详细信息    查看全文

• 作者：Elizabeth C. Griffith ; Rebecca J. Rapf ; Richard K. Shoemaker ; Barry K. Carpenter ; Veronica Vaida
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：March 12, 2014
• 年：2014
• 卷：136
• 期：10
• 页码：3784-3787
• 全文大小：224K
• 年卷期：v.136,no.10(March 12, 2014)
• ISSN：1520-5126

文摘

The aqueous photochemistry of 2-oxooctanoic acid (a single-tailed surfactant) results in the synthesis of a double-tailed surfactant product followed by spontaneous self-assembly into vesicles. The photochemical mechanism is detailed here, and the reaction products are identified using mass spectrometry. Then, the self-assembled vesicles are characterized using dynamic light scattering, fluorescence microscopy, and NMR. Further, their stability over time and in the presence of MgCl₂ salt is demonstrated. This work contributes to membrane evolution through the provision of a prebiotic route for the synthesis of plausible membrane components and subsequent self-assembly of a primitive enclosure.