Catalytic Macrocyclization Strategies Using Continuous Flow: Formal Total Synthesis of Ivorenolide A

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• 作者：Mylène de Léséleuc ; Éric Godin ; Shawn Parisien-Collette ; Alexandre Lévesque ; Shawn K. Collins
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：81
• 期：15
• 页码：6750-6756
• 全文大小：455K
• 年卷期：0
• ISSN：1520-6904

文摘

A formal total synthesis of ivorenolide A has been accomplished employing a Z-selective olefin cross metathesis and a macrocyclic Glaser–Hay coupling as key steps. The macrocyclization protocol employed a phase separation/continuous flow manifold whose advantages include catalysis, fast reaction times, high concentrations, and facile scale-up.