Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene

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• 作者：Suresh Kumar Sythana ; Surendra R. Naramreddy ; Santosh Kavitake ; Vinod Kumar CH. ; Pundlik R. Bhagat
• 刊名：Organic Process Research & Development
• 出版年：2014
• 出版时间：July 18, 2014
• 年：2014
• 卷：18
• 期：7
• 页码：912-918
• 全文大小：296K
• ISSN：1520-586X

文摘

A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.